Melrose Homes for Sale

Melrose Homes for Sale

Welcome to Melrose, Florida – a hidden gem nestled between the picturesque lakes and lush landscapes of North Central Florida. This charming town offers a unique blend of small-town charm and natural beauty, making it an ideal destination for those looking to escape the hustle and bustle of city life. With its serene ambiance and friendly community, Melrose is perfect for families, retirees, and anyone in search of a peaceful retreat.

As you explore Melrose, you'll discover a variety of homes for sale that cater to diverse lifestyles and tastes. From cozy cottages and modern ranch-style homes to spacious family residences, there is something for everyone in this delightful town. Many properties boast stunning views of the surrounding lakes and nature, allowing you to embrace the tranquility of the great outdoors right from your backyard.

Melrose is not just about beautiful homes; it also offers an array of recreational opportunities. Spend your weekends fishing, boating, or hiking in the nearby parks and nature reserves. The town is also home to friendly local shops, delicious dining options, and vibrant community events that foster a strong sense of belonging.

With its affordable real estate options and a welcoming atmosphere, Melrose is quickly becoming a sought-after destination for those looking to invest in their dream home. Explore the homes for sale in this enchanting town and discover the perfect place to create lasting memories. Your idyllic Florida lifestyle awaits in Melrose!

Newest Melrose Homes for Sale

657 Se 2nd Avenue, Melrose
$479,000
3 Beds ⋅ 4 Baths ⋅ Seminole Ridge #6 SubDv. ⋅ 32666 Zip Code
Beautiful Seminole Ridge Home! This 3 bedroom 3.5 bath home has 3093 sq ft of living space and sits on 1.6 acres in a park like setting. The home was updated in 2024 with new roof, AC, and submersible well & tank. It has a spacious great room with vaulted ceilings and tubular skylights. The kitchen has granite countertops, a large pantry, stainless steel appliances, plenty of cabinetry, breakfast bar, and a breakfast nook for casual dining. The bedrooms have walk in closets and en suite bathrooms. The bedroom adjacent to the family room could be used as an in-law suite. The laundry room has a half bath and lots of storage. There’s an all purpose room off the kitchen with hot tub that leads to the screen porch and concrete patio. The home has a detached 2 carport and attached 1 car carport that connects to a workshop. The back yard has privacy fencing and a shed and the whole property is made up of three parcels, one in Bradford and two in Clay. Come and see this home will not last!

657 Se 2nd Avenue, Melrose
6898 Cr 214, Melrose
$263,500
3 Beds ⋅ 2 Baths ⋅ 32666 Zip Code
***Seller is willing to contribute toward the buyer’s closing costs with an acceptable offer.*** Beautifully updated and move-in ready, this 3-bedroom, 2-bath home offers 1,829 square feet of living space in Melrose. The spacious family room features recessed lighting, large windows that bring in plenty of natural light, and plenty of room to relax, gather, or entertain. The open layout connects the family room to the dining area and updated kitchen, creating a bright and welcoming living space. The kitchen features white cabinetry, stainless steel appliances, plenty of counter space, and a large island with seating. LVP flooring runs throughout the main living areas, while both bathrooms have been beautifully updated with modern finishes and tile work. An indoor laundry room adds everyday convenience. Outside, you'll find a spacious backyard with mature trees and plenty of room to enjoy the outdoors. The home also features a 2023 roof. Conveniently located just minutes from the upcoming Aldi in Melrose, Winn-Dixie, Keystone Beach and Park, local restaurants, and everyday services, with easy access to both Keystone Heights and Gainesville. Enjoy a quieter setting while still keeping the places you need close by.

6898 Cr 214, Melrose
241 Se 5th Avenue, Melrose
$599,999
3 Beds ⋅ 2 Baths ⋅ Seminole Ridge #2 SubDv. ⋅ 32666 Zip Code
WATERFRONT LIVING ON THE CANAL TO LAKE SANTA FE! This spacious 3-bedroom, 2-bath waterfront home offers 2,301 square feet of heated and cooled living space with an ideal blend of comfort, functionality, and outdoor living. The interior features a welcoming living room, dedicated office area, dining space, and a well-appointed kitchen with prep island—perfect for everyday living and entertaining. The oversized primary bedroom is truly impressive, measuring approximately 31 feet in length and offering plenty of room to relax and unwind. Step outside to the lanai and take in peaceful waterfront views overlooking the boat house and boat lift. The outdoor living area is designed for enjoying the Florida lifestyle, featuring an inviting in-ground pool and hot tub. With canal access to Lake Santa Fe, this property offers an exceptional opportunity for boating, recreation, and waterfront enjoyment right at home. A unique combination of spacious indoor living, private outdoor amenities, and direct water access makes this Lake Santa Fe-area home a must-see.

241 Se 5th Avenue, Melrose
752 N State Road 21, Melrose
$264,900
3 Beds ⋅ 2 Baths ⋅ Whitehead & Files Surv SubDv. ⋅ 32666 Zip Code
If being near Lake Santa Fe and lower property taxes sounds like what you're looking for, this home is for you. With only being five minutes from the lake, it makes backing down the boat, riding your jet ski, and fishing easy to do. On 1.85 acres, you'll immediately feel at ease as soon as you enter the property. This beautiful and unique concrete block home is elevated off the ground with no worries of flooding and invites you in with its natural light and warm, welcoming atmosphere. With an open layout, this home is perfect for entertaining, and areas to work from home or have a playroom area. You'll find 3 cozy bedrooms and 2 charming bathrooms here. Beyond the kitchen is a Florida Room with beautiful nature views where doing laundry will feel more enjoyable and less like a chore. Right outside the fully-fenced front and backyard, sits raised garden beds waiting for your plants and green thumb. There is a large garage perfect for storing your tools, using it as a workshop, housing your outdoor toys, or the perfect opportunity if you have a business - with its own separate electric meter! Around the back of the home you can access the basement where your water heater, plumbing and water softener system are all situated for easy access. Beautiful fruit trees (loquat, kumquat and orange) stand throughout the property. Bonus is an RV hookup nestled in the rear of the property. This home is situated in Melrose (Putnam County) conveniently located 20-30 minutes to Gainesville, providing a much smoother commute compared to other surrounding cities. Located throughout the charming town are local-loved restaurants such as Fryers, Gator Bait, and Blue Water Bay and beautiful parks such as Jill McGuire Santa Fe Lake Park, Melrose Bay Park, and Melrose Heritage Park. You can have it all here with an idyllic retreat at home, lake living, small-town charm and nearly everything just around the corner! 5 year old Roof, HVAC, and Water Heater. New Roof on Garage/Workshop. 100% Financing Available!

752 N State Road 21, Melrose
7217 Ne 221st Street, Melrose
$239,500
3 Beds ⋅ 2 Baths ⋅ N/A SubDv. ⋅ 32666 Zip Code
GREAT LOCATION JUST STEPS TO SANTE FE LAKE. CAN BE A GOOD "GET AWAY ESCAPE HOME" FOR ANYONE. NOT A LARGE PLACE BUT HAS A PLEASANT COUNTRY CHARM. 3RD BEDROOM HAS A BUILT IN MURPHY BED. VERY POPULAR AREA WITH THE SNOW BIRDS. PROBABLY A GREAT SHORT TERM RENTAL OPPORTUNITY FOR EXTRA INCOME. JUST MINUTES TO MELROSE TO THE EAST AND GAINESVILLE TO THE WEST. SEVERAL EXTRA STORAGE BUILDINGS STAY. GREAT PLACE FOR PEACE AND QUIET.

7217 Ne 221st Street, Melrose
202 Mason Road, Melrose
$1,190,000
6 Beds ⋅ 6 Baths ⋅ South Lake Rosa SubDv. ⋅ 32666 Zip Code
Welcome to an extraordinary lakefront retreat where space, character, and spectacular water views come together on beautiful Lake Rosa in Melrose, Florida. This one-of-a-kind property offers not just one exceptional home, but two residences, creating an incredible opportunity for a large family, multigenerational living, guests, or those looking for a private lakefront getaway with additional space on an expansive 9.2 acres. The magnificent main residence offers an impressive 5,187 square feet of heated and cooled living space, featuring 4 bedrooms and 4 1/2 bathrooms. From the moment you drive onto the property, you will feel you have entered a park with the beautifully manicured grounds, which include 1000 planted, mature camellias. Once inside the main house you will take in vaulted ceilings and the expansive and breathtaking lake views that set the tone for relaxed lakefront living. You'll find wonderful spaces designed for both entertaining and everyday enjoyment, including two loft areas, a cozy fireplace, wet bar, and a wine cellar—perfect for evenings spent with friends and family after a day on the lake. The generous living spaces provide plenty of room to spread out while still maintaining the warm, inviting feel you'd expect from a true lake home. The outside decks from this home give over 3000 sq ft of additional space to enjoy the outdoors from many rooms and levels of the home. And then there's the second residence, offering an additional 2,496 square feet of heated and cooled living space, with 2 bedrooms and 1 bathroom. Complete with its own deck overlooking the lake, this separate home is ideal for guests, extended family, a caretaker, or anyone who wants their own private space while still being just steps from all the lakefront fun. With a combined 7,683 square feet of heated and cooled living space and 6 total bedrooms, this is far more than a home—it's a lakefront lifestyle and an opportunity that's hard to duplicate. Imagine morning coffee with the lake as your backdrop, afternoons enjoying the water from your private dock and evenings gathered around the fireplace or relaxing on the deck as the day winds down. Whether you're looking for a spectacular full-time residence, a weekend escape, or a property designed for entertaining generations of family and friends, this one delivers the space, setting, and character to make lake memories for years to come. Come experience the magic of Lake Rosa for yourself—this is lake living with room for everyone!

202 Mason Road, Melrose
5930 Island Road, Melrose
$398,000
2 Beds ⋅ 2 Baths ⋅ Canal Shores Sub SubDv. ⋅ 32666 Zip Code
Nestled on Island Road in Melrose, escape to your private waterfront oasis on the desirable Santa Fe Canal, with direct access to the expansive 6,000-acre Santa Fe Lake. This beautifully updated 2-bedroom, 2-bath home blends indoor comfort with outdoor Florida living-all just minutes from a public boat ramp and picnic area. Detached 2-car garage for storage, projects, or extra parking. Sprinkler system keeps the landscape lush with minimal effort. Canal-side deck ideal for cookouts, fishing, or relaxing by the water. Recent major updates: HVAC (2023), water heater (2024) plus many more recent improvements throughout. Vaulted ceiling with a stone-accent gas fireplace creates a warm, open great room. Split bedroom floor plan for privacy and flexibility. Enclose sunroom-perfect for morning coffee or enjoying outdoors from inside.

5930 Island Road, Melrose
377 Se 4th Avenue, Melrose
$395,000
3 Beds ⋅ 2 Baths ⋅ Seminole Rdg Un No 5 SubDv. ⋅ 32666 Zip Code
Under Construction. BEAUTIFUL NEW CONSTRUCTION IN DESIRABLE MELROSE! Welcome home to this beautifully crafted new construction by D.R. Baker Construction, offering quality, comfort, and thoughtful design on a spacious half-acre lot in desirable Melrose, Bradford County. Just one block from Lake Santa Fe, this 3-bedroom, 2-full-bath home offers an inviting blend of modern style and relaxed Florida living. Step inside to a bright and welcoming open-concept floor plan featuring over 1,551 square feet of living space, high ceilings, and abundant natural light. The spacious kitchen is designed for both everyday living and entertaining, with an open layout and center island that creates the perfect gathering spot for family and guests. The desirable split-bedroom floor plan provides privacy for the spacious primary suite, which features elegant tray ceilings, a generous walk-in closet, and a light and bright primary bathroom. Two additional bedrooms and a full bath offer plenty of room for guests or a home office. An oversized inside utility room provides excellent storage and workspace, adding everyday convenience to this thoughtfully designed home. Step outside and enjoy your morning coffee or unwind at the end of the day from either the front or back covered porch. The beautiful half-acre lot provides room to enjoy the peaceful surroundings and embrace the laid-back lifestyle that makes Melrose so special. Located in Melrose, Bradford County, with an easy commute to Gainesville, Orange Park, and Palatka, this home offers a wonderful opportunity to enjoy new construction, a beautiful setting, and convenient access to surrounding communities. Come see the quality and beauty of a D.R. Baker Construction home for yourself!

377 Se 4th Avenue, Melrose
22304 Ne 35th Avenue, Melrose
$574,000
3 Beds ⋅ 2 Baths ⋅ Country Square Estates SubDv. ⋅ 32666 Zip Code
Looking for a private hideaway where you can slow down and enjoy the peaceful country lifestyle? Welcome to this one-of-a-kind retreat nestled on nearly 19 beautiful acres in Melrose. This custom home is filled with warmth and character, featuring stunning hardwood floors, exceptional custom woodwork throughout, and a spacious great room highlighted by a soaring vaulting ceiling and cozy wood-burning fireplace. Expansive covered front and back porches stretch the full length of the home, providing the perfect place to relax, entertain, or simply take in the peaceful views of the surrounding property. Outside, the possibilities are endless. With nearly 19 acres, there's plenty of room for horses, gardening, outdoor recreation, or creating your own private homestead. Whether you're seeking a full-time residence or a weekend country escape, this property offers the perfect blend of privacy, comfort, and natural beauty. Come experience everything this country retreat has to offer!

22304 Ne 35th Avenue, Melrose
8443 Lilly Lake Road, Melrose
$495,000
3 Beds ⋅ 2 Baths ⋅ Lilly Lake SubDv. ⋅ 32666 Zip Code
Welcome to Lilly Lake, where peaceful lakefront living meets stylish modern comfort. Nestled on the crystal-clear, spring-fed waters, this fully upgraded 3-bedroom, 2-bath home offers the perfect retreat from the hustle and bustle of city life. Step inside to a bright, sun-filled interior featuring luxury vinyl flooring throughout, a cozy wood burning fireplace, and tasteful designer finishes that create a warm yet elegant atmosphere. Every detail has been thoughtfully updated, making this home truly move-in ready. The outdoor living space is just as impressive. A spacious lakefront deck provides the perfect setting for entertaining guests, enjoying morning coffee, or simply taking in the breathtaking views. Down by the water, you'll find your own private boat ramp, boat lift, and an elevated sitting area-ideal for watching sunsets or relaxing by the lake. If you've been dreaming of peaceful waterfront living with modern upgrades and year-round recreation, this is the perfect home.

8443 Lilly Lake Road, Melrose
8315 Lilly Lake Road, Melrose
$814,900
6 Beds ⋅ 4 Baths ⋅ Opal Lake SubDv. ⋅ 32666 Zip Code
Where Lake Life Meets Country Comfort! Imagine waking up beneath a canopy of mature oaks, spending your afternoons beside the pool, and ending the day with the peaceful beauty of private Lake Opal just beyond your door. Welcome to a truly special Melrose retreat—an expansive 4,425-square-foot brick home nestled on 1.69 acres of picturesque lakefront property. Designed for both comfortable everyday living and unforgettable gatherings, this six-bedroom, four-bath home offers the space, flexibility, and setting today's buyers are looking for. Inside, the heart of the home is the generous kitchen and inviting family spaces, where gatherings naturally become the centerpiece of everyday life. A spacious family room flows into a dedicated game room, complete with a pool table and built-in ping-pong table—creating an ideal setting for holidays, weekend guests, or simply enjoying time together. Need room for everyone? You have it. The home includes six bedrooms, the in-law suite features its own private entrance—perfect for extended family, guests, multigenerational living, or a private home office arrangement. One bedroom offers excellent flexibility as a dedicated office, study, or creative space. Storage is anything but an afterthought. A huge pantry/storage area, large laundry room with built-in drop zone and ironing board, plus additional storage beneath the pool deck provide practical solutions for everything from everyday organization to outdoor equipment. And then there is the lifestyle. Step outside and enjoy your own private oasis with a pool, hot tub, lake views, fenced yard, dog run, RV hookup, and oversized parking. Mature trees provide shade and privacy while Lake Opal creates a beautiful backdrop for quiet mornings, weekend recreation, fishing, swimming, and sunset gatherings. Sit on the pool deck and watch the wildlife frolicking in the back yard! With a metal roof, brick exterior, private well and septic system, this property combines enduring construction with the relaxed appeal of lake-country living. Located in the Melrose/Keystone Heights area, the property offers a peaceful retreat while remaining conveniently positioned for access to Gainesville, Ocala, St. Augustine, and Jacksonville. More Than a Home—It's a Place to Gather, Unwind & Make Memories. Whether you're looking for a spacious primary residence, a multigenerational home, a private lake retreat, or simply a property where family and friends can come together, 8315 Lilly Lake Road, Melrose offers an uncommon combination of space, privacy, recreation, and waterfront living. Come experience Lake Opal living for yourself. New Drain Field added Sept 2026, final inspection paperwork to be added to the Disclosures as soon as it is received. Also, some fresh paint is occurring. All Dragons are excluded from the sell.

8315 Lilly Lake Road, Melrose
561 Se 28th Street, Melrose
$367,000
3 Beds ⋅ 2 Baths ⋅ Boykin SubDv. ⋅ 32666 Zip Code
Welcome to a beautiful waterfront retreat in the heart of Lake Geneva Estates in Melrose, Florida—where everyday living feels like a private getaway. This exceptional 3-bedroom, 2-bath canal-front home offers the perfect rural living: sweeping water views underneath the most beautiful oak trees. From the moment you arrive, the paved driveway leads you to an inviting entrance that sets the tone for what’s inside. Step through the door into a spacious open-concept living area where high ceilings and a panoramic layout seamlessly connect the living room, kitchen, and dining space. The kitchen is designed for both function and gathering, featuring abundant counter space and sleek stainless steel appliances. Anchoring the living room is a warm brick wood-burning fireplace, creating a cozy focal point that flows naturally into the Florida room—where walls of windows showcase stunning canal and island views. The primary suite is a peaceful retreat with a generous walk-in closet and a private en-suite bath. An interior utility room adds everyday convenience and functionality. Outdoor living is where this property truly shines. An oversized garage provides ample storage, while the screened lanai invites you to relax and take in serene views of the canal just beyond your backyard. A patio overlooks lush green grass that invites all the wildlife to entertain you—your own natural sanctuary waiting to be explored. Nature surrounds you here, with frequent sightings of whistling wood ducks, sandhill cranes, deer, and more, creating a peaceful and vibrant wildlife backdrop. Tucked away in a quiet, desirable neighborhood, this property offers the rare combination of privacy, waterfront living, and convenience—just minutes from local restaurants, shopping, and everyday essentials. And best of all—NO HOA. Offered at $397,500, this is more than a home—it’s a lifestyle, a retreat, and an extraordinary opportunity to own a slice of Florida paradise. *Additional 8.2 acre island lot available at $97,000

561 Se 28th Street, Melrose
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